Marfan's Syndrome is inherited, which should be considered by the prospective mother. Pregnancy can be high risk for Marfan's patients because of the elevated blood pressure and blood volume and is not recommended for individuals with an aortic root that exceeds 40mm in diameter. Aortic rupture may occur during pregnancy, or as its consequence for up to 6 months after delivery.

Anyone with congenital heart disease, repaired or non-repaired, should consult with their cardiologist prior to becoming pregnant to review the risks.